What they discovered was that Bacillus strains had 'quorum sensing.' Their thinking was, and it was a simple but brilliant idea, that it was not about supra-dosing a single strain but whether bacteria could positively impact the hundred trillion population of the microbiome as a whole.Īfter extensive research, they found that there were microbes that could organize the microbiome into a healthy, homeostatic population even at low doses. Physicians Exclusive (the company behind MegaSporeBiotic™) set out to identify specific bacteria strains that could make a big difference to the microbiome. Optimal gut health depends on a balanced microbiome. While this approach helped to suppress symptoms, it did not restore health.
So, when we inundate our body with one genus of bacteria through fermented foods or probiotics, we can cause dysbiosis.īefore MegaSporeBiotic™, antihistamine strains of probiotics merely alleviated histamine intolerance symptoms. In contrast, lactobacillus makes up around 1% of a healthy gut, so it's a relatively small player. Most last-generation probiotics on the market, and most fermented foods, are high in lactobacillus.
#Mega spore driver#
We now know that gram-negative bacteria's high presence also causes many gut conditions associated with histamine intolerance, such as SIBO, celiac disease, and dysbiosis.Īlso, gram-negative bacteria are the biggest driver of leaky gut and chronic inflammation in the gut and the body.Īs you start to see a shift towards more gram-negative bacteria, particularly in the small intestine dominated by gram-positive bacteria, you start to see histamine intolerance creep up. It is not a toxin coming into the gastrointestinal tract from outside (such as contaminated or high histamine food)-instead, it's generated within the gut. Gram-negative bacterium only has a cell membrane that consists of lipopolysaccharides (LPS).Įndotoxins are toxins produced within the gut. The gram-positive bacterium has a cell wall structure that does not absorb the dye. Which category it belongs to depends upon its gram stain.Ī gram stain is a way of putting a dye-like stain on the bacterium, which, when absorbed, colors gram-positive bacteria. Having now tested and worked with hundreds of people, MegaSporeBiotic™ is the next-generation probiotic that works to rebalance the microbiome.Įvery bacterium in the world belongs to one of two categories – gram-negative or gram-positive. Instead, we can now focus on restoring our gut function's health. We are no longer focused on fermented foods or high-dose single or multi-strain probiotics for gut health, which may worsen things. We are no longer restricted to trying to control symptoms with low histamine probiotics and ever-decreasing elimination diets, many of which cut out the very things we need for gut health. Much of our prior focus and many of our tools have changed. This has allowed us to improve our understanding of the gut biome dramatically. We can now map the whole microbiome for a minimal cost. Histamine intolerance physical level probiotic Jul 29, 2022
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